Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors

Genetically engineered T cells with Chimeric Antigen Receptors, CAR cells, are a revolutionary immunotherapy used to treat advanced blood cancers. The purpose of this experiment was model the destruction process tumor cell therapy using Complexity and Organized Behaviour Within Environmental Bounds (COBWEB), an agent-based simulation software. We designated parameter values for abiotic factors, agents (i.e. cells) general environment in our illustrate interactions between cytotoxic components, which described binding innate CD8+ or antigens. models were observe comparatively analyze rate solid by cells. developed circular island 60 ticks, representing days; then able infiltrate population monitored over 500 days. exhibited significantly powerful, efficient immune response against relative yet relapse occurred both albeit lesser extent However, further investigations required adequately simulate side effects realistically-limiting factors therapy. Similar comparative analyses may help measure compare potency compared standard, lack of, treatments.